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The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery Review

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Engineering 2024, Volume 32, Issue 1,   Pages 19-29 doi: 10.1016/j.eng.2023.09.011

Abstract:

G protein-coupled receptors (GPCRs) are crucial players in various physiological processes, makingIn conclusion, continued advancements in AI techniques coupled with interdisciplinary collaborations

Keywords： G protein-coupled receptor     Ligand     Artificial intelligence     Multi-omics     Drug discovery    

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G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 482-491 doi: 10.1007/s11684-018-0633-0

Abstract: LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon

Keywords： LGR6     colon adenocarcinoma     immunohistochemistry     prognosis    

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Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 166-170 doi: 10.1007/s11684-008-0030-1

Abstract: This study aims to demonstrate that blocking the receptor-interacting protein2 (Rip2) expression canconcentration was assayed with ELISA and high-mobility group box 1 protein (HMGB1) level with semi-quantitativeRip2 siRNA plasmid could block the mRNA and protein expression of Rip2 and promote cell proliferationThe HMGB1 expression in the liver decreased to (40.21 ± 11.03) pg/g, and serum TNF-?
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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: Proteinase-activated receptors (PARs) are a novel subclass of seven transmembrane-spanning, G protein-coupledIn the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 218-226 doi: 10.15302/J-FASE-2020324

Abstract: The relationship of spatial structural characteristics of the spike protein, a protein that is critical

Keywords： bat     coronavirus     evolution     host receptor     spike protein     transmission    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases. We found the variation in two families with type 2 diabetes mellitus by D-HPLC mutation screening method and confirmed our results by direct sequencing and PCR-RFLP. Although without changing the amino acid coding, the variance may have an effect on codon usage and play a role in disease development, such as type 2 diabetes mellitus. However, we cannot define the role of this variance because the frequency of the minor allele is low in the Chinese population and no homozygote of the variance was found. More research in multiple populations will be necessary to define the role of this variance.

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogen activated protein

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 97-104 doi: 10.15302/J-FASE-2018248

Abstract: The N-end rule pathway of protein degradation is also directly linked to NLR stability.

Keywords： E3 ubiquitin ligase     degradation     nucleotide-binding leucine-rich repeat receptor     plant immunity     proteasome     protein stability     ubiquitination    

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A method for quantifying bias in modeled concentrations and source impacts for secondary particulate matter

Mulholland, Armistead G. Russell

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0866-6

Abstract: A method for quantifying source impacts for secondary PM species is derived. The method provides estimates of bias in modeled concentrations. Adjusted concentrations match corresponding observations at monitored locations. Sources impacts on secondary species are estimated over the US for 20 sources. Community Multi-Scale Air Quality (CMAQ) estimates of sulfates, nitrates, ammonium, and organic carbon are highly influenced by uncertainties in modeled secondary formation processes, such as chemical mechanisms, volatilization, and condensation rates. These compounds constitute the majority of PM mass, and reducing bias in estimated concentrations has benefits for policy measures and epidemiological studies. In this work, a method for adjusting source impacts on secondary species is developed that provides estimates of source contributions and reduces bias in modeled concentrations compared to observations. The bias correction adjusts concentrations and source impacts based on the difference between modeled concentrations and observations while taking into account uncertainties at the location of interest; and it is applied both spatially and temporally. We apply the method over the US for 2006. The mean bias for initial CMAQ concentrations compared to observations is −0.28 (OC), 0.11 (NO ), 0.05 (NH ), and −0.08 (SO ). The normalized mean bias in modeled concentrations compared to observations was effectively zero for OC, NO , NH , and SO after applying the secondary bias correction. 10-fold cross-validation was conducted to determine the performance of the spatial application of the bias correction. Cross-validation performance was favorable; correlation coefficients were greater than 0.69 for all species when comparing observations and concentrations based on kriged correction factors. The methods presented here address model uncertainties by improving simulated concentrations and source impacts of secondary particulate matter through data assimilation. Secondary-adjusted concentrations and source impacts from 20 emissions sources are generated for 2006 over continental US.

Keywords： Particulate matter     Source apportionment     Secondary particulate matter     Chemical transport modeling     Receptor    

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Preparation of copolymer-grafted mixed-mode resins for immunoglobulin G adsorption

Shenggang Chen, Tao Liu, Ruiqi Yang, Dongqiang Lin, Shanjing Yao

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 70-79 doi: 10.1007/s11705-018-1745-4

Abstract: The mixed-mode resins for protein adsorption have been prepared by a novel strategy, copolymer graftingBesides, METAC and ABI provided positive effects together in both protein adsorption and elution: dynamicbinding capacity of human Immunoglobulin G (hIgG) onto CG-M-A resin with the highest ligand ratio ofMETAC to ABI is 46.8 mg·g at pH 9 and the elution recovery of hIgG is 97.0% at pH 5.

Keywords： atom transfer radical polymerization     copolymer-grafting     mixed-mode resin     protein adsorption    

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Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID

Luning Yang, Ke Xie, Zhisheng Huang, Lixue Huang, Xiaoying Gu, Hui Li, Yi Zhang, Yimin Wang, Frederick G.

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 601-612 doi: 10.1007/s11684-020-0800-y

Abstract: The possible effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers

Keywords： COVID-19     SARS-CoV-2     hypertension     angiotensin-converting enzyme inhibitor     angiotensin II receptor blocker    

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A high-isolation coupled-fed building block for metal-rimmed 5G smartphones Correspondence

Aidi REN, Chengwei YU, Lixia YANG, Wei CUI, Zhixiang HUANG, Ying LIU

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 11,   Pages 1657-1664 doi: 10.1631/FITEE.2300203

Abstract: A dual-antenna building block with high isolation is presented for metal-rimmed fifth-generation (5G)A coupled-fed loop antenna and a coupledfed slot antenna based on a simple T-slot etched on the groundNotably, although the coupledfed loop antenna and the coupled-fed slot antenna share the same aperture
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REINTEGRATION OF CROP-LIVESTOCK SYSTEMS IN EUROPE: AN OVERVIEW

Antonius G. T. SCHUT, Emily C. COOLEDGE, Marc MORAINE, Gerrie W. J. VAN DE VEN, Davey L.

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 1,   Pages 111-129 doi: 10.15302/J-FASE-2020373

Abstract: Ongoing specialization of crop and livestock systems provides socioeconomic benefits to the farmer but has led to greater externalization of environmental costs when compared to mixed farming systems. Better integration of crop and livestock systems offers great potential to rebalance the economic and environmental trade-offs in both systems. The aims of this study were to analyze changes in farm structure and review and evaluate the potential for reintegrating specialized intensive crop and livestock systems, with specific emphasis on identifying the co-benefits and barriers to reintegration. Historically, animals were essential to recycle nutrients in the farming system but this became less important with the availability of synthetic fertilisers. Although mixed farm systems can be economically attractive, benefits of scale combined with socio-economic factors have resulted in on-farm and regional specialization with negative environmental impacts. Reintegration is therefore needed to reduce nutrient surpluses at farm, regional and national levels, and to improve soil quality in intensive cropping systems. Reintegration offers practical and cost-effective options to widen crop rotations and promotes the use of organic inputs and associated benefits, reducing dependency on synthetic fertilisers, biocides and manure processing costs. Circular agriculture goes beyond manure management and requires adaptation of both food production and consumption patterns, matching local capacity to produce with food demand. Consequently, feed transport, greenhouse gas emissions, nutrient surpluses and nutrient losses to the environment can be reduced. It is concluded that reintegration of specialized farms within a region can provide benefits to farmers but may also lead to further intensification of land use. New approaches within a food system context offer alternatives for reintegration, but require strong policy incentives which show clear, tangible and lasting benefits for farmers, the environment and the wider community.

Keywords： circular agriculture     coupled farming systems     mixed farming     specialised farming systems     GHG    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Title Author Date Type Operation

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Journal Article

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma

Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang

Journal Article

Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages

LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein

Baicheng HUANG, Kegong TIAN

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Journal Article

A method for quantifying bias in modeled concentrations and source impacts for secondary particulate matter

Mulholland, Armistead G. Russell

Journal Article

Preparation of copolymer-grafted mixed-mode resins for immunoglobulin G adsorption

Shenggang Chen, Tao Liu, Ruiqi Yang, Dongqiang Lin, Shanjing Yao

Journal Article

Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID

Luning Yang, Ke Xie, Zhisheng Huang, Lixue Huang, Xiaoying Gu, Hui Li, Yi Zhang, Yimin Wang, Frederick G.

Journal Article

A high-isolation coupled-fed building block for metal-rimmed 5G smartphones

Aidi REN, Chengwei YU, Lixia YANG, Wei CUI, Zhixiang HUANG, Ying LIU

Journal Article

REINTEGRATION OF CROP-LIVESTOCK SYSTEMS IN EUROPE: AN OVERVIEW

Antonius G. T. SCHUT, Emily C. COOLEDGE, Marc MORAINE, Gerrie W. J. VAN DE VEN, Davey L.

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article